A New Mathematical Model for the Optimization of the Mobile Phase Composition in Hptlc and the Comparison with Other Models
نویسنده
چکیده
Mobile phase optimization is highly important in planar chromatography. Solvent selection based on experience and chromatographic intuition can be very time consuming when applied to complex mixtures. In these cases, more systematic strategies are needed. This paper presents a new mathematical model for the optimization of the mobile phase composition used for the separation of a mixture of 1,4-benzodiazepines and a comparison of this mathematical approach with other models. INTRODUCTION Mobile phase composition is highly important in thin layer chromatography (TLC). From the early days of chromatography as an analytical tool for the separation and determination of multi-component mixtures, great effort has been made in the field of optimization because of specific problems encountered in liquid chromatography.
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تاریخ انتشار 1999